There are 5 ways to get from Madrid to Santa María de Cayón by train, bus, car or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.
Recommended option
Train
-
Take the train from Madrid-Chamartin to Santander
4 alternative options
Bus
-
Take the bus from Madrid to Santander
Drive
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Drive from Madrid to Santa María de Cayón
Fly to Santander, bus
-
Fly from Madrid (MAD) to Santander (SDR)
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Take the bus from Santander to Santa Maria De Cayon
Fly to Bilbao, bus
-
Fly from Madrid (MAD) to Bilbao (BIO)
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Take the bus from Bilbao to Santander
-
Take the bus from Santander to Santa Maria De Cayon
Madrid to Santa María de Cayón by train and bus
Travel safe during COVID-19
Rules to follow in Spain
1.5m
Mandatory
Travel within Spain
Observe COVID-19 safety rules
COVID-19 help in Spain
If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 112
Frequently Asked Questions
There are currently travel restrictions within Spain.
Explore options for future travelDomestic travel is not restricted, but some conditions may apply
- Face masks are mandatory
- There is a social distancing requirement of 1.5 metres
- Observe COVID-19 safety rules
The national COVID-19 helpline number in Santa María de Cayón is 112.
Wearing a face mask on public transport in Santa María de Cayón is mandatory.
The social distance requirement in Santa María de Cayón is 1.5 metres.
Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 112.
Last updated: 28 Jul 2022
Exceptions may apply, for full details: European Union.
We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.
Questions & Answers
The most affordable way to get from Madrid to Santa María de Cayón is to train, which costs €35 - €50 and takes 6h 49m.
The quickest way to get from Madrid to Santa María de Cayón is to drive which costs €80 - €120 and takes 4h 18m.
No, there is no direct bus from Madrid to Santa María de Cayón. However, there are services departing from Madrid and arriving at Santa Maria De Cayon via Santander. The journey, including transfers, takes approximately 7h 20m.
The distance between Madrid and Santa María de Cayón is 322 km. The road distance is 443.3 km.
The best way to get from Madrid to Santa María de Cayón without a car is to train which takes 6h 49m and costs €35 - €50.
It takes approximately 6h 49m to get from Madrid to Santa María de Cayón, including transfers.
Madrid to Santa María de Cayón bus services, operated by ALSA, depart from Madrid station.
The best way to get from Madrid to Santa María de Cayón is to train which takes 6h 49m and costs €35 - €50. Alternatively, you can bus, which costs €35 - €55 and takes 7h 20m.
The quickest flight from Madrid Airport to Santander Airport is the direct flight which takes 1h 5m.
Madrid to Santa María de Cayón bus services, operated by ALSA, arrive at Santander station.
- Distance: 322 km
- Duration: 6h 49m
What companies run services between Madrid, Spain and Santa María de Cayón, Spain?
Renfe Viajeros operates a train from Madrid-Chamartin to Santander 3 times a day. Tickets cost €28 - €35 and the journey takes 4h 4m. Alternatively, ALSA operates a bus from Madrid to Santander every 4 hours. Tickets cost €35 - €50 and the journey takes 5h 45m.
- Website
- iberia.com
Flights from Madrid to Santander
- Ave. Duration
- 1h 9m
- When
- Every day
- Estimated price
- €35 - €230
Flights from Madrid to Bilbao
- Ave. Duration
- 1h 3m
- When
- Every day
- Estimated price
- €45 - €190
- Website
- aireuropa.com
Flights from Madrid to Bilbao
- Ave. Duration
- 58 min
- When
- Every day
- Estimated price
- €35 - €170
Spain's excellent and extensive rail system connects cities across Spain and into neighbouring countries. Renfe's high-speed AVE trains can reach speeds of up to 350km/h, making travel between major cities very efficient. All medium- and long-distance trains require a seat reservation; ticket sales for these trains usually open 30-60 days before travel. Most Renfe trains have two classes: Turista (2nd class) and Preferente (1st class), although some AVE trains offer Turista Plus. There is free WiFi for Preferente passengers and for those with a +Renfe loyalty card.
Rome2rio's guide to Renfe Viajeros
Contact Details
- Phone
- +34 91 232 03 20
- comunicacion@renfe.es
- Website
- renfe.com
Train from Madrid-Chamartin to Santander
- Ave. Duration
- 4h 4m
- Frequency
- 3 times a day
- Estimated price
- €28 - €35
- Website
- Renfe Viajeros
A Spanish subsidiary of National Express, ALSA provides bus and coach services across Spain and neighbouring countries including Portugal, France, Germany, the Netherlands, Italy, Poland and Malta. Founded in 1923, ALSA values service and the customer experience. Buses are equipped with communal TV screens showing movies, individual behind-seat screens, ALSA radio, app for books and music, and free WiFi. ALSA services are accessible to people with disabilities, and guide dogs are welcome on all journeys. There are three types of tickets on offer (Frequent Traveller Pass, Share Pass and ALSA Pass), along with discounts for senior citizens, students and children.
Contact Details
- Phone
- +34 902 42 22 42
- alsa@alsa.es
- Website
- alsa.es
Bus from Madrid to Santander
- Ave. Duration
- 5h 45m
- Frequency
- Every 4 hours
- Estimated price
- €35 - €50
- Website
- alsa.com
Bus from Santander to Santa Maria De Cayon
- Ave. Duration
- 35 min
- Frequency
- Every 4 hours
- Estimated price
- €3 - €5
- Website
- alsa.com
Bus from Bilbao to Santander
- Ave. Duration
- 1h 20m
- Frequency
- Hourly
- Estimated price
- €9 - €13
- Website
- alsa.com
One of Europe’s leading bus companies, Flixbus serves 2000+ destinations in 29 countries, including Germany, France, Italy, Austria, the Netherlands and Croatia and into Scandinavia and eastern Europe, as well as some US cities. Coaches have toilets, free WiFi and power outlets, plus snacks and drinks for purchase on board. Flixbus is a good choice for the budget-conscious traveller; purchase tickets in advance for the cheapest fares (note: there is no option to reserve a seat in advance).
Rome2rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.de
Bus from Bilbao to Santander
- Ave. Duration
- 1h 10m
- Frequency
- Once daily
- Estimated price
- €8 - €10
- Website
- flixbus.co.uk
Frequently asked questions
- Phone
- 902 999 748
- Website
- web.bilmanbus.es
Bus from Bilbao to Santander Bus Station
- Ave. Duration
- 2h
- Frequency
- Once daily
- Schedules at
- web.bilmanbus.es
Want to know more about travelling around Spain
Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Rome2rio’s guide has all the details
Read the travel guideMore Questions & Answers
Yes, the driving distance between Madrid to Santa María de Cayón is 443 km. It takes approximately 4h 18m to drive from Madrid to Santa María de Cayón.
Iberia offers flights from Madrid Airport to Santander Airport.
Book your Madrid to Santa María de Cayón bus tickets online with Omio and Busbud.
There are 1196+ hotels available in Santa María de Cayón. Prices start at €100 per night.